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San Antonio Medical Foundation

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The goal of this project is to optimize the culture and purification conditions for production of recombinant Coccidioides antigens using a fungal expression system. We have created two transformed Uncinocarpus reesii clones (CTS1ur and BGL2ur) that can produce recombinant Coccidioides antigens (rCTSur and rBGL2ur), respectively. We will develop purification protocol to produce high yield of these two Coccidioides antigens for development of rapid diagnosis assays.

The University of Texas at San Antonio
Hung, Chiung-Yu