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San Antonio Medical Foundation

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The objective of this research proposal is to further prove the concept that peptide mimics of the protective epitopes of PI-LPS are sufficient to confer protective immunity against C. burnetii aerosol infection. As a subcontract, Dr. Zhang will provide expert advice and guidance in experimental designing, data interpretation and problems solving as needed by ZenVax LLC in support of this project. In order to facilitate the ZenVax LLC’s effort to develop a mimotope vaccine against Q fever, Dr.

The University of Texas at San Antonio
Zhang, Guoquan

The major goal of this project, using a model of Kawasaki disease in mice, is to selectively turn off the FSTL-1 gene at different times during the onset and development of the disease, and evaluate if, and how, FSTL-1 affects the heart damage seen in Kawasaki disease in order to develop an effective treatment strategy for Kawasaki disease's long term effects.

Texas Biomedical Research Institute
Patterson, Jean