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Trending Research

Top viewed research performed by San Antonio Bioscience Organizations

RAPAMYCIN AS A THERAPY FOR VASCULAR DAMAGE IN ALZHEIMER'S DISEASE
UT Health San Antonio
Galvan Hart,Veronica
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SGLT2 INHIBITION AND STIMULATION OF ENDOGENOUS GLUCOSE PRODUCTION

Inhibition of the renal SGLT2 transporter has proven to be an effective therapeutic interventionto reduce plasma glucose levels and HbA1c in type 2 diabetic patients. The glycemic-loweringefficacy of the SGLT2 inhibitors results from two distinct mechanisms: (i) induction ofglucosuria, which amounts to ~70-90 grams per day and (ii) amelioration of glucotoxicity leadingto increased insulin sensitivity in muscle and improved beta cell function (JCI 124:509-514,2014).

UT Health San Antonio
DeFronzo, Ralph A
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