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This renewal application stems from our successful first four years of a Bridge-to-the-Doctorate grant (SouthTexas Doctoral Bridge Program (STDBP; 2013-2017) supporting a partnership between the University ofTexas Health Science Center at San Antonio (UT Health San Antonio; PhD-granting) and Texas StateUniversity ? San Marcos (TxState, master's granting).

UT Health San Antonio
Oyajobi, Babatunde

Metabolic disorders including obesity, dyslipidemia and diabetes appear to be associated with monocyte dysfunction, yet the molecular mechanisms underlying monocyte dysfunction in vivo are only poorly understood. Our recent studies showed that metabolic stress promotes the dysregulation and hyper-activation of monocyte responses to chemokines and that monocyte dysfunction is a critical and rate-limiting step in the development and progression of atherosclerosis.

UT Health San Antonio
Asmis, Reto H.R.