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San Antonio Medical Foundation

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A first-of-its-kind initiative between public and private sector to catalog and highlight Bioscience research in the city of San Antonio and the surrounding areas.

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THE SINGLE CELL BIOPSY AND CHARACTERIZATION CORE (SBCC) AT THE UNIVERSITY OF TEXAS HEALTH SCIENCE AT SAN ANTONIO
UT Health San Antonio
Huang,Hui-Ming
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INVESTIGATING THE ROLE OF TRANSPOSABLE ELEMENT DYSREGULATION AS A DRIVER OF NEUROTOXICITY IN TAUOPATHY

Transposable elements, known colloquially as ?jumping genes,? constitute approximately 45% of the humangenome. Cells utilize epigenetic defenses to limit transposable element jumping, including formation of silencingheterochromatin and generation of piwi-interacting RNAs (piRNAs), small RNAs that facilitate clearance oftransposable element transcripts. Transposable element activation has recently been identified as a keymediator of neuronal death in tauopathies, a group of neurodegenerative disorders that are pathologicallydefined by deposits of tau protein in the brain.

UT Health San Antonio
Frost, Susan Elizabeth
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