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Candidiasis represents a leading cause of hospital?acquired bloodstream infections in the U.S. with anattributable mortality rate of 40-60%. Candida albicans, a major opportunistic human fungal pathogenresponsible for the majority of candidiasis cases, can cause a wide variety of systemic and mucosal infections.Immunocompromised individuals, including organ transplant recipients, AIDS patients, and cancer patients onchemotherapy, are particularly susceptible.

UT Health San Antonio
Kadosh, David

Adipose tissue-derived mesenchymal stem cells (AD-MSCs) have the potential to serve as a critical toolfor bone tissue engineering as their relatively high frequency in the body can provide the exceedingly largenumbers of cells required for regenerative therapies. Unfortunately, many studies have shown that AD-MSCshave considerably less osteogenic potential than other types of stem cells. Our group has developed an invitro-produced extracellular matrix (ECM) that recapitulates specific attributes of the native bone marrow (BM-)and adipose (AD-) microenvironment.

UT Health San Antonio
Marinkovic, Milos