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A PHASE 3, MULTI-NATIONAL, DOUBLE-BLIND RANDOMIZED, PLACEBO-CONTROLLED, STRATIFIED, PARALLEL GROUP STUDY TO EVALUATE THE SAFETY, TOLERABILITY AND EFFICACY OF TIRASEMTIV IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS (ALS)
UT Health San Antonio
Jackson,Carlayne E
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THE HIPPO SIGNALING PATHWAY IN PANCREATIC EPITHELIAL CELLS ORCHESTRATE THE INFLAMMATORY RESPONSE

The inflammatory disorders of the pancreas have two forms, acute and chronic. Acute pancreatitiscauses severe illness and reduces life expectancy. However, besides supportive care, there is no effectivetreatment for the disease due to a lack of understanding of the early cellular events important in thepathophysiology of this disease. Not only is chronic pancreatitis as bad in that it does not heal or improve andonly gets worse over time leading to permanent damage of the pancreas, it is also the top risk factor forpancreatic adenocarcinoma (PDAC).

UT Health San Antonio
Wang, Pei
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