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San Antonio Medical Foundation

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There are three major accomplishments resulting from this project that significantly advance the field of TMJ biomechanics and will form the basis of a new research project. First, we have developed a high-fidelity, anatomically accurate, finite-element model of TMJ mechanics that is governed by the internal generation of muscle forces to achieve a specific functional goal (such as chewing), paralleling how functional joint motion is produced in vivo (Figure 1).

Southwest Research Institute
Daniel P. Nicolella, Ph.D.; Jessica S. Coogan, Ph.D.; Travis D. Eliason; Todd L. Bredbenner, Ph.D.

Schistosomes are the most important of the helminth parasites that infect humans. Larval stages infect aquatic snails, so the transmission cycle can be broken by interfering with this stage in the parasite lifecycle. We will use genetic crosses of schistosomes in the laboratory to identify the parasite genes that underlie recognition of snail vectors and development of parasites within host snails.

Texas Biomedical Research Institute
Anderson, Timothy J. C.