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19-003 We propose a study to investigate the risk of TB reactivation in BCG vaccinated marmosets that are treated with Secukinumab. Role: PI

Texas Biomedical Research Institute
Kaushal, Deepak

Cellular senescence causes inflammation, oxidative stress, and mitochondrial dysfunction, which have been implicated in the pathogenesis of age-related diseases. Accordingly, genetic depletion of senescent cells has recently been shown to extend lifespan and attenuate aging-related diseases. However, the cellular mechanisms underlying senescence and how it may promote diseases of aging are unclear. Recent work from my laboratory has implicated a role for ALCAT1 in linking cellular senescence with aging-related diseases.

UT Health San Antonio
Shi, Yuguang