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Ca2+ is a critical second messenger that is required for several cellular processes. Cytosolic Ca2+ (cCa2+)transients are shaped by the mitochondria due to the highly negative membrane potential and through themitochondrial calcium uniporter (MCU). Mitochondrial Ca2+ (mCa2+) is utilized by the matrix dehydrogenases formaintaining cellular bioenergetics. Reciprocally, dysregulated elevation of cCa2+ under conditions of stroke,ischemia/reperfusion injury drives mCa2+ overload that in turn leads to mitochondrial permeability transition poreopening that triggers necrotic cell death.

UT Health San Antonio
Muniswamy, Madesh

The purpose of this study is to evaluate the effect of LCZ696 compared to valsartan in the reduction of cardiovascular death and heart failure(HF) hospitalizations in patients with HF with preserved ejection fraction.

Brooke Army Medical Center
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