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Top viewed research performed by San Antonio Bioscience Organizations

Perturbation of antigen-specific T cell responses in latent TB/SIV co-infection

The major goal is to identify antigen-specific T cell responses in macaques with LTBI and SIV co-infection. Here we have infected some animals with Mtb to develop LTBI, while others naturally progress to ATB. Further, some of the animals have been co-infected with SIV (n=6) and 4 of which reactivated and 2 didn't. In the years to come we will focus on generating more LTBI, ATB, R, NR animals and also perform SIV ART treatment. Eventually antigen-specific responses to ESAT-6, CFP-10, and CW will be evaluated in the peripheral as well as lung samples. Role: MPI

Texas Biomedical Research Institute
Kaushal, Deepak
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A Phase 3, Multicenter, Open-Label Extension Trial Of Oral RPC1063 As Therapy For Moderate To Severe Ulcerative Colitis

This is an open-label, multicenter, extension trial to evaluate the long term safety and efficacy of RPC1063 in patients with moderately to severely active ulcerative colitis (UC). Patients who have previously participated in a trial of RPC1063 for UC will be eligible for entry in this trial if they meet the eligibility criterion for participation as outlined in the prior trial.

Brooke Army Medical Center
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