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San Antonio Medical Foundation

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The current therapy for diabetes patients is suboptimal as many endure complications leading to blindness, kidney failure, amputations, heart failure and stroke. We propose to develop unique stem cells engineered from skin or blood cells of patients and coaxed into insulin producing cells, which will be then microencapsulated and grafted under the skin of a patient. This proposal will help support the initial testing in the baboon model of diabetes developed at Texas Biomed.

Texas Biomedical Research Institute
Daadi, Marcel

Emerging evidence supports the proposition that the mitochondrial respiratory chain (MRC) functions viaorganized multicomplex structures called supercomplexes. However the dynamics and regulation ofsupercomplex assembly have not been fully investigated. In particular, hardly any regulatory protein factorsinvolved in supercomplex assembly have been identified. Our long term goal is to understand the dynamics ofmitochondrial respiratory machinery and its underling regulatory mechanism.

UT Health San Antonio
Bai, Yidong