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San Antonio Medical Foundation

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Project summary/abstract: The long-term career goal of Dr. Arunabh Bhattacharya is to establish himself asa successful and well-funded, independent investigator through sustained basic and translational research inthe field of aging, in particular, in the area of muscle biology. His doctoral and postdoctoral training in the areaof inflammatory diseases and oxidative stress laid the foundation for this career development awardapplication. His research career to date has been highly productive with more than 38 publications in peer-reviewed journals.

UT Health San Antonio
Bhattacharya, Arunabh

Aberrant activation of the B cell receptor (BCR) is an emerging hallmark of mature B cell tumors. The BCR initiates a signaling cascade that activates multiple kinases, including SYK, BTK and PI3K?, leading to engagement of the NF-?B, PI3K/AKT, RAS and MAPK pathways, thus promoting proliferation/survival of B cells. Considering this pro-growth outcome, it is not surprising that malignant B cells hijack this signaling module for their benefit.

UT Health San Antonio
Cooney, Jeffrey