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San Antonio Medical Foundation

A Collaboration of the San Antonio Bioscience and Medical Research Community

A first-of-its-kind initiative between public and private sector to catalog and highlight Bioscience research in the city of San Antonio and the surrounding areas.

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Top viewed research performed by San Antonio Bioscience Organizations

MMI-T32 Training Pre-doctoral Scientists in Molecular Microbiology and Immunology at UTSA

Scholarship & Fellowship

The University of Texas at San Antonio
Cardona, Astrid; Lopez-Ribot, Jose; Mathur, Ambika
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ROLE OF BRCA1 PHOSPHORYLATION IN DNA DSB REPAIR AND GENOME STABILITY MAINTENANCE

The tumor suppressor BRCA1 plays an important role in the homologous recombination (HR) pathwayof DNA double strand break (DSB) repair. From a mechanistic perspective, BRCA1 facilitates recruitment ofnucleases required for end resection, the commitment step in HR repair, yet paradoxically, BRCA1 has beenshown to inhibit the nuclease activity in vitro. It is unclear how nuclease-recruiting and -inhibiting activities ofBRCA1 can be reconciled in HR repair.

UT Health San Antonio
Hu, Yanfen
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