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San Antonio Medical Foundation

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Top viewed research performed by San Antonio Bioscience Organizations


Alcohol consumption impairs motor coordination, attentional efforts and memory function. Alcohol-impaireddriving accounted in 2013 for ~31% of all traffic accidents resulting in 10,076 fatalities and $59 billion crash-related cost. We propose to study the mechanisms how ethanol affects brain state-dependent neuralsignaling. Brain state-dependent signaling comprises adjustments in cellular and circuit activity to optimizehow the brain processes information in a distinct behavioral context.

UT Health San Antonio
Paukert, Martin

The hypothalamus is the brain hub that regulates energy homeostasis. The genetic and molecular basis of thisregulation in humans is not well understood as access to this tissue is a major barrier and available onlypostmortem. To overcome the barrier of limited tissue access, we are generating induced pluripotent stem cell(iPSC)-derived neuronal cultures that recapitulate many of the features of hypothalamic neurons from thearcuate nucleus, including by benchmarking this in vitro model to in vivo events that are pivotal in hypothalamicdevelopment.

UT Health San Antonio
Lehman, Donna M