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San Antonio Medical Foundation

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PROJECT SUMMARY
 Interrogation of basic biological phenomena in the post-genome era relies heavily on high-throughput. sensitive technologies that provide molecular profiles of cells and tissues. High-dimensionality molecular measurements (e.g.. levels of mRNAs for many/all genes) can be readily accomplished in bulk samples and down to the single-cell level. producing comprehensive (???omics) profiles for given samples that address research needs. However. such techniques necessarily ignore the tissue localization of gene products in order to produce the high-dimensionality data.

The University of Texas at San Antonio
Hermann, Brian; Renthal, Robert; Seshu, Janakiram; Rathbone, Christopher; Cassill, J

To develop therapeutic approaches for addressing the COVID-19 pandemic. this project brings together researchers with multidisciplinary and complementary expertise in theoretical and computational biophysics (PI Vashisth. UNH). biophysical chemistry and NMR spectroscopy (co-PI Varga. UNH). and small- molecule drug discovery (co-PI Doug E. Frantz. UTSA). The partnership and collaboration are timely and strategic in that the first experimental structure of the protease enzyme and its potential inhibitors have just been reported. Dr.

The University of Texas at San Antonio
Frantz, Douglas