The central hypothesis of this research project is that rheostat positions have general properties that distinguish them from other nonconserved positions. In Aim 1. we will test the hypothe- sis that rheostat positions can be detected by a particular pattern of evolutionary change. using pyruvate kinase. aldolase. and an organic anion transmembrane transporter as model systems. If prediction is possible. amino acid variants at rheostat positions should be ??? for now ??? classified as having ???unknown significance??? to reduce false predictions. Further.
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The University of Texas at San Antonio
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The University of Texas at San Antonio
The University of Texas at San Antonio