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San Antonio Medical Foundation

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There are three major accomplishments resulting from this project that significantly advance the field of TMJ biomechanics and will form the basis of a new research project. First, we have developed a high-fidelity, anatomically accurate, finite-element model of TMJ mechanics that is governed by the internal generation of muscle forces to achieve a specific functional goal (such as chewing), paralleling how functional joint motion is produced in vivo (Figure 1).

Southwest Research Institute
Daniel P. Nicolella, Ph.D.; Jessica S. Coogan, Ph.D.; Travis D. Eliason; Todd L. Bredbenner, Ph.D.

Type 2 diabetes mellitus (T2DM) affects ~29.1 million individuals in the US and is associated withsignificant morbidity and mortality from both microvascular and macrovascular complications. Themicrovascular, and to a lesser extent macrovascular, complications primarily are related tohyperglycemia. Therefore, it is logical to initiate therapy early in the natural history of T2DM, at the?prediabetic? stage, with interventions that reverse specific pathophysiologic defects present in IGT andIFG.

UT Health San Antonio
DeFronzo, Ralph A