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San Antonio Medical Foundation

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Oral health is associated with nutritional intake and overall well-being in elderly populations and progressivelydeteriorates with aging. In addition, salivary gland function, which plays a major role in oral defense, alsodecreases with age. However, the mechanisms involved in this age-related decline have not beencomprehensively studied due to a lack of proper laboratory animal models for studying changes in oral healthwith aging. The common marmoset is a relatively short-lived non-human primate (NHP) that recapitulates manyof the physiological changes that occur in human aging.

UT Health San Antonio
Yeh, Chih-Ko

Cognitive impairment has a serious detrimental impact on the quality of life for prostate cancer survivorstreated by androgen deprivation therapy (ADT). Neuroimaging studies have shown structural and functionaldeficits in the medial prefrontal cortex (mPFC) and hippocampus (Hipp), which mediate higher order cognitiveprocesses, including cognitive flexibility and spatial cognition, that are impaired after ADT. In this project, we willinvestigate mechanisms that underly the cognitive impairments we have now shown to be induced by androgendeprivation in rats.

UT Health San Antonio
Morilak, David A