Facilitated By

San Antonio Medical Foundation

A Collaboration of the San Antonio Bioscience and Medical Research Community

A first-of-its-kind initiative between public and private sector to catalog and highlight Bioscience research in the city of San Antonio and the surrounding areas.

Trending Research

Top viewed research performed by San Antonio Bioscience Organizations

KDM1A INHIBITION ENHANCES ERB MEDIATED TUMOR SUPPRESSION IN OVARIAN CANCER
UT Health San Antonio
Sareddy, Gangadhara Reddy
More Info
Folate and Psma Interact to Regulate Dna Methylation and Prostate Carcinogenesis

Folate, as part of the one carbon cycle, is critical for the de novo synthesis of S-adenosyl methionine (SAM). SAM, in turn, provides the methyl group for DNA methylation, a key mode of epigenetic regulation. Studies have shown that manipulation of folate levels during gestation alters the epigenetic status of genes, and that treatment with methyl donors in adulthood reverses DNA methylation changes. Given the effect of folate levels on DNA methylation, it is not surprising that dietary folate status influences the risk for several cancers. Folate is also essential for cell proliferation.

UT Health San Antonio
O'keefe, Denise Susan
More Info