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Acute kidney injury (AKI) and chronic kidney disease (CKD) are major contributors to overall morbidity andmortality in patients in the US. The overall objective of the proposed study is to establish untargeted andtargeted spatial metabolomics analysis of tissues from normal and diseased kidneys to assess cellularmetabolic states associated with healthy function, acute injury, chronic condition, and recovery.

UT Health San Antonio
Sharma, Kumar

This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study of Cenicriviroc (CVC) for the treatment of Stage 2 to 3 liver fibrosis in adult subjects with Non-Alcoholic Steatohepatitis (NASH). The study will be conducted in 2 parts: Part 1 (surrogate endpoint) and Part 2 (clinical outcomes). Part 1: Approximately 1000 subjects will be randomized. Approximately 667 subjects are to receive CVC and approximately 333 subjects are to receive placebo. Subjects who remain in Part 1 at Month 12 will continue to receive the same treatment assignment in Part 2.

Brooke Army Medical Center
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