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A Master Protocol Of Phase 1/2 Studies Of Nivolumab In Advanced Nsclc Using Nivolumab As Maintenance After Induction Chemotherapy Or As First-Line Treatment Alone Or In Combination With Standard Of Care Therapies

Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality worldwide, accounting for approximately 18% of all cancer deaths.1 Despite treatment with platinum-based chemotherapy, the standard of care for first-line therapy, patients with metastatic NSCLC have a median survival of approximately 10 months, and a 5-year survival rate of less than 5%. Immunotherapeutic approaches have demonstrated clinical efficacy in several cancer types, including melanoma, hormone-refractory prostate cancer, and lung cancer.3,4.

Brooke Army Medical Center
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ERI: Toward Unfolding the Effect of Sex Variations in Biomechanics of Traumatic Brain Injury

Traumatic brain injury (TBI) and many other brain diseases/injuries exhibit sex differences in prevalence. onset. and outcomes. Some of these differences are attributed to the fact that the human brain is sexually dimorphic and there are certain regional and structural differences that exist between male and female brains. However. the effect of these sex variations in biomechanical responses of brain have not been elucidated. The paucity of sex-specific knowledge in brain biomechanics and TBI fields is mainly due to the fact that. these fields have predominantly focused on males.

The University of Texas at San Antonio
Hajiaghamemar, Marzieh
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