Blocking SARS-CoV-2 evasion from innate antiviral defenses
Principal Investigator(s)
Martinez-Sobrido, Luis
Collaborating Institutions
University of Texas Health Science Center San Antonio
Funded by
San Antonio Partnership for Precision Therapeutics
Research Start Date
Status
Active
We aim to develop a high-throughput fluorescent assay of Orf10-CUL2 binding; identify candidate inhibitors of Orf10-CUL2 binding by computational screening; evaluate impact of these molecules on SARS-CoV-2 replication in cell-based assays and in the mouse model; and develop medicinal chemistry infrastructure for optimization of Orf10 inhibitors.