Comprehensive SNP Discovery in SLC2A9. A Candidate Gene for Uric Acid Nephropathy
Principal Investigator(s)
Cole, Shelley A.
Funded by
University of North Carolina
Research Start Date
Status
Active
Increased serum uric acid or hyperuricemia is a risk factor for kidney and heart disease and gout. The uric acid transporter SLC2A9 regulates uric acid concentrations in blood by regulating uric acid reabsorption and secretion in kidneys. Alteration in the transporter activity can result in hyperuricemia thus increasing the risk for kidney disease gout and heart disease. Thus evaluating the complete variation in the SLC2A9 gene will help us gain better understanding of the mechanism in Mexican Americans as well as American Indians. In addition, this study may provide novel targets for treating these painful diseases and ameliorate their complications.