CONTINUED DEVELOPMENT AND MAINTENANCE OF THE ULTRASCAN SOFTWARE

We propose to continue development and support for the UltraScan-III (US3) software suite, acomprehensive toolkit for the analysis of data from hydrodynamic experiments and hydrodynamicsimulations. Such experiments include analytical ultracentrifugation, small angle X-ray and neutronscattering experiments, as well as bead model simulations. Support for this project will assure futureavailability of a mature multi-platform analysis suite with important and unique capabilities not found inany other software packages. Chief among them are tight integration of supercomputing capabilities,LIMS support for collaboration, and specialized analysis routines. US3 enjoys widespread use in theAUC and SAXS/SANS communities, and offers the most robust optimization and simulation algorithmsavailable, resulting in unmatched detail, and provides the highest throughput, a flexible, modern GUI,and a comprehensive list of analysis routines. Among the proposed developments are support for thenext generation of three new multi-wavelength detection capable AUC instruments which will enableparadigm-changing solution studies of complex systems where components with distinctchromophores can be simultaneously separated based on both their spectral and hydrodynamicproperties. Further enhancements include many algorithm improvements, porting of AUC and SOMOcodes to the latest 3rd party C++ frameworks, supporting new operating systems such as 64-bitsupport on Windows, and enabling uniform integration of UltraScan-SOMO in the US3 class libraries.