Corticosteroid Eluting Endotracheal Tube to Mitigate Airway Inflammation Associated with COVID-19

This proposal addresses developing advanced airway devices for use during respiratory failure and prolonged intubation to deliver therapeutics during intubation for acute respiratory distress syndrome. In a broader context. controlled therapeutic delivery from our endotracheal tube platform may serve a larger role in preventing and treating ventilator associated pneumonia. Our novel ET tube coating provides the additional potential of drug delivery. We propose to employ our existing. novel laryngotracheal models delivering therapeutics to vocal folds. temperature dependent laryngotracheal injury models. and longitudinal laryngeal burn models to assess drug delivery efficacy from our polymer-coated endotracheal tube.