Facilitated By

San Antonio Medical Foundation

Eliminating autoantibody-producing plasma cells in neuroinflammation via ERK inhibition

The University of Texas at San Antonio

The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.

Principal Investigator(s)
Forsthuber, Thomas
Funded by
Natl Inst of Health
Research Start Date

B cell-depleting therapies using anti-CD20 monoclonal antibodies have been successful for the treatment of relapsing-remitting multiple sclerosis (RRMS); however, B cell-depletion showed incomplete efficacy for the treatment of autoantibody-mediated autoimmune conditions, including Systemic Lupus Erythematosus (SLE) and neuromyelitis optica (NMO), most likely because of the failure to eliminate autoantibody-producing long-lived plasma cells (PCs). Novel approaches to eliminate autoantibody-producing PCs are therefore urgently needed.We will test the central hypothesis that ERK2-signaling is critical for generation and survival of autoantibody-producing LLPCs in bone marrow and CNS niches.

Collaborative Project
Basic Research