Facilitated By

San Antonio Medical Foundation

Identification of Regulatory Loci of Stx2a Cytotoxin Production in Enterohemorrhagic Escherichia coli O157:H7

The University of Texas at San Antonio

The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.

Principal Investigator(s)
Eppinger, Mark
Funded by
Natl Inst of Health
Research Start Date
Status
Active

Enterohemorrhagic Escherichia coli (EHEC) of the O157:H7 serotype are notorious for the producing
 highly potent Shiga toxin. which is a direct mediator of life-threatening global human disease. In this proposal. we
 will systematically identify loci in EHEC O157:H7 genome that determine the amount of cytotoxin produced.
 Findings are of major public health relevance by providing attractive targets for improved biosurveillance.
 diagnostics risk assessment and development of novel therapeutic anti-Stx strategies suppressing toxin production
 during human infection with translational application for the collective group of human pathogenic Shiga toxin
 producing E. coli.

Collaborative Project
Basic Research
Infectious Disease