Facilitated By

San Antonio Medical Foundation

Impact of Physical Activity on Striatal Reinnervation in a Nonhuman Primate Model of Parkinson's Disease

Texas Biomedical Research Institute

 

As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.

Principal Investigator(s)
Marcel Daadi
Funded by
NIH
Research Start Date
Status
Active

In this multidisciplinary proposal we will use a nonhuman primate model of Parkinsons disease to study the reversibility of the beneficial effects of physical exercise and its impact on induced pluripotent stem cell (iPSC)-based therapy. We will investigate how exercise and iPSC-based cell therapy reinnervate the striatum and restore movement and gait by recruiting new neural networks as revealed by longitudinal multimodal imaging, behavioral and morphological analysis.

Collaborative Project
Disease Modeling
Basic Research
Regenerative Medicine