Facilitated By

San Antonio Medical Foundation

Impact of Physical Activity on Striatal Reinnervation in a Nonhuman Primate Model of Parkinson's Disease

Texas Biomedical Research Institute


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Principal Investigator(s)
Marcel Daadi
Funded by
Research Start Date

In this multidisciplinary proposal we will use a nonhuman primate model of Parkinsons disease to study the reversibility of the beneficial effects of physical exercise and its impact on induced pluripotent stem cell (iPSC)-based therapy. We will investigate how exercise and iPSC-based cell therapy reinnervate the striatum and restore movement and gait by recruiting new neural networks as revealed by longitudinal multimodal imaging, behavioral and morphological analysis.

Collaborative Project
Disease Modeling
Basic Research
Regenerative Medicine