Lipid Mediators of Macrophage Metabolism and Immune Responses to Mycobacterium tuberculosis
Principal Investigator(s)
Leopold Wager, Chrissy M
Funded by
Cowles Memorial Trust
Research Start Date
Status
Active
The major goals of this project is to determine the mechanisms used by M.tb to persist in the macrophage environment via its activation of host PPAR?. The studies herein represent the next steps to elucidating the role of eicosanoids, critical players at the interface of inflammation and metabolism, in M.tb survival and growth and provide a foundation for the transition to in vivo models of TB. Txbiomed Project: 4692