Facilitated By

San Antonio Medical Foundation

Microphysiological models of the upper airway to evaluate pathogen resistance

The University of Texas at San Antonio

The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.

Principal Investigator(s)
Guda, Teja
Seshu, Janakiram
Flores, Mario
Funded by
Research Start Date

In light of the currently extant Covid pandemic. the impact of understanding upper airway health and being prepared for the rapid development of novel therapeutics has been reinforced. While preclinical animal models have long been the gold standard for the testing and development of novel therapeutics. they are expensive and time consuming. The availability of validated. reproducible and scalable in vitro diagnostics that reproduce relevant physiology and function as test-benches for the rapid testing and development of personalized medicine therapeutics is thus invaluable. In pursuit of this goal. we propose to develop an upper airway -on-chip" platform that takes into account the unique air-liquid interface of airway physiology. the inflammatory response of systemic tissue and a robust multi-omics approach to predicting outcomes for physiological and pathological tissue states. The novel platform would only be possible through the synergistic integration of bioengineers. biologists and machine learning experts as in the team assembled for this proposal."

Collaborative Project
Basic Research
Medical Devices
Drug Discovery
Disease Modeling
Infectious Disease
Regenerative Medicine