Facilitated By

San Antonio Medical Foundation

Molecular Determinants of HIV hypermutation

Texas Biomedical Research Institute

 

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Principal Investigator(s)
Ebrahimi, Diako
Funded by
National Institutes of Health
Research Start Date
Status
Active

We have discovered that human APOBEC3 genes produce enzymes with different sizes and activities in different human populations. Importantly, the mutations induce, by APOBEC3 enzymes, in the HIV-1 genome also have distinct patterns in different human populations. The major goals of this study are to establish association between genetic variations in the APOBEC3 locus and variations in HIV-1 hypermutation patterns, and determine the underlying molecular mechanisms.

Collaborative Project
Basic Research
Disease Modeling
Infectious Disease