A Neonatal Monkey Model for Tuberculosis Vaccination
Principal Investigator(s)
Gauduin, Marie-Claire
Collaborating Institutions
University of Texas Health Science Center Houston
Funded by
National Institutes of Health
Research Start Date
Status
Active
The major goal of this proposal is to vaccinate neonatal macaques with recombinant, TLR-2 stimulating, BCG vaccine, which can induce central memory T cells, and thereby generate long-term immunity against tuberculosis. We will, therefore: 1) Evaluate TH1 immune responses induced by wild type and recombinant BCG vaccine in neonatal macaques; 2) evaluate efficacy of wild type and recombinant BCG vaccines against tuberculosis in neonatal macaques; and, 3) evaluate long-term efficacy of wild type and recombinant BCG vaccines using in neonatal macaques.