Roles of the Nucleoprotein 3'-5' Exonuclease Domain in Arenavirus Biology
Principal Investigator(s)
Martinez-Sobrido, Luis
Collaborating Institutions
The Scripps Research Institute
Funded by
National Institutes of Health
Research Start Date
Status
Active
Morbidity and mortality associated with human mammarenavirus infections involve a failure of the host's innate immune response to restrict virus multiplication at early stages of infection, thus compromising the initiation of an effective innate and adaptive immune response to control and eliminate the virus. Studies in this application will provide a better understanding of arenavirus-host innate defense interactions, which can facilitate the development of novel strategies to combat human pathogenic mammarenaviruses.