Facilitated By

San Antonio Medical Foundation

Roles of the Nucleoprotein 3'-5' Exonuclease Domain in Arenavirus Biology

Texas Biomedical Research Institute

 

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Principal Investigator(s)
Martinez-Sobrido, Luis
Collaborating Institutions
The Scripps Research Institute
Funded by
National Institutes of Health
Research Start Date
Status
Active

Morbidity and mortality associated with human mammarenavirus infections involve a failure of the host's innate immune response to restrict virus multiplication at early stages of infection, thus compromising the initiation of an effective innate and adaptive immune response to control and eliminate the virus. Studies in this application will provide a better understanding of arenavirus-host innate defense interactions, which can facilitate the development of novel strategies to combat human pathogenic mammarenaviruses.

Collaborative Project
Basic Research
Infectious Disease