SA-CCRC-Development of Therapeutics and Vaccines Against Coccidioidomycosis.
This CCRC U19 proposal is composed of 1 administrative core. 3 scientific projects and 2 scientific cores.We have assembled a team of experts to develop novel therapeutic drugs and vaccines against coccidioidomycosis.The Co-PI/PDs are Dr. Chiung-Yu Hung and Jose Lopez-Ribot The 3 projects are: 1. Project#1 Title: Screening repurposing libraries for the identification of drugs with novel anti-coccidioidal activity Co-Leads: Dr. Jose Lopez-Ribot and Dr. Jieh-Juen Yu at Biology Department. UTSA 2. Project#2 Title: Relationship between in vitro antifungal resistance and in vivo response in coccidioidomycosis Co-Leads: Dr. Thomas Patterson and Dr. Nathan Wiederhold at UT Health San Antonio 3. Project#3 Title: Active vaccination and immunotherapy against coccidioidomycosis Lead: Dr. Chiung-Yu Hung at UTSA. The 2 scientific cores are 1. BSL3 drug screening core. Lead: Dr. Jose Lopez-Ribot 2. Cell-Genomics-Bioinformatics core. Co-Leads: Dr. Astrid Cardona. Dr. Brian Herman and Dr. Yufeng Wang.