Single Cell Genomics for Malaria Parasites-IHC

Infections with malaria parasites frequently contain both multiple Plasmodium species and multiple haplotypes from each species. Multiple species and haplotype infections impact disease severity, the spread of drug resistance and basic population genetic parameters, and complicate even basic genetic analysis. This study applies novel approaches developed in our laboratory which address this problem by generating whole genome sequence from single parasite-infected cells. We will apply these to human infections to refine our understanding of the complexity of malaria infections.