Small Molecule Regulation of Mitochondrial Ca2+ Uniporter (MCU) Channel for Treatment of Multi-Organ Failure
Principal Investigator(s)
Ebrahimi, Diako
Collaborating Institutions
University of Texas Health Science Center San Antonio
Funded by
San Antonio Partnership for Precision Therapeutics
Research Start Date
Status
Active
The goal of the project is to understand the pathways operative in sepsis and the necessity for improved therapies. Ee will develop a small molecule screening program using in silico drug design strategies based on the crystal and CryoEM structure of MCU-ligand interaction for identification and synthesis of novel small molecules that could be further tested for next generation MCU regulators.