Applied Research

Basic Research

In the diabetic retina disruption of fractalkine (FKN) signaling induces fibrin(ogen) deposition. increased production of IL-1??? by microglia. vascular and neuronal damage.But. how FKN and its receptor. CX3CR1. regulate microglia activation and retinal pathology is unknown.In humans. two single nucleotide polymorphisms in the CX3CR1 locus (hCX3CR1-I249/M280) that show defective binding to FKN. play a key role in inflammation during diabetes.Induction of diabetes in a mouse model expressing the human CX3CR1-I249/M280 revealed accelerated neuronal loss in the retina.

Obesity. a chronic imbalance in energy homeostasis between energy intake and energy expenditure. is a public health crisis and continues to be among the most important medical challenges in the U.S.A. Obesity creates a greater than $190 billion burden annually on American healthcare. The development of therapeutic approaches that lessen or eliminate obesity-associated morbidity and mortality would have a transformative impact on the American population and healthcare spending. There are two types of adipose tissue in mammals: white adipose tissue which is specialized for energy storage.

Acquisition and deployment of the CrimeEye video surveillance system with Genetec video analytics that will allow our security team to maximize their efforts to keep our campus secure by having better situational awareness through enhanced monitoring, verification and validation of threats improving security response times.

This major goal of this funding is to outfit the Pathology Unit of SNPRC with a new chemistry analyzer, a new slide stainer and coverslipper, as well as seeks to purchase a state of the art whole slide scanner, which will provide a significant upgrade to research capabilities supported by Texas Biomed.

Core instrumentation for the Biology Core to expand the flow cytometry capabilities.

The purpose of this grant is for the purchase of a Confocal Microscope for Core Research Support project.

The major goal is to increase primate holding capacity for the P51 base grant.

In the diabetic retina disruption of fractalkine (FKN) signaling induces fibrin(ogen) deposition, increased production of IL-1b by microglia, vascular and neuronal damage.  But, how FKN and its receptor, CX3CR1, regulate microglia activation and retinal pathology is unknown.  In humans, two single nucleotide polymorphisms in the CX3CR1 locus (hCX3CR1-I249/M280) that show defective binding to FKN, play a key role in inflammation during diabetes.  Notably, assessments of the effect of hCX3CR1-I249/M280 in an animal model revealed that express