The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Sung, Patrick M
Funded by
NIH-NATIONAL CANCER INSTITUTE
Collaborating Institutions
COLORADO
Proteins from the Fanconi anemia (FA) pathway play an integral role in DNA repair by homologousrecombination (HR). FA is a multigenic disorder marked by progressive bone marrow failure and astrong cancer predisposition. Numerous studies have linked mutations in FA genes to familial breast,pancreatic, and other cancers, and have also provided ample evidence to implicate silencing of FAgenes in the etiology of sporadic cancers.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Flores, Shahida K
Funded by
NIH-GENERAL MEDICAL SCIENCES
Endocytosis is a conserved pathway that internalizes macromolecules and transmembrane proteins and sortsthem through the endo-lysosomal system to their destinations. This process is often dysregulated in manydiseases including cancers, metabolic disorders and neurodegenerative diseases. Elucidating the endocyticmechanisms of transmembrane proteins will improve our understanding of biological processes, diseaseprognosis and therapeutic strategies.
