Numerous studies have indicated that pain is the top ranked symptom in head and neck cancer (HNC)patients. However, available treatments are limited and associated with severe side effects addingsubstantially to the burden of having cancer. Thus, there is a critical need for novel analgesics.

The San Antonio Breast Cancer Symposium (SABCS) is a five day international symposium thatprovides state-of-the-art information on translational research in breast cancer both for basicscientists and clinicians who work directly with patients.

This competing renewal application requests a second five-year support by the Ruth Kirschstein NationalResearch Service Award (T32) for our ?Cancer Biology Training Program? based at the University of TexasHealth Science Center at San Antonio (UTHSCSA), a Hispanic-Serving Institution.

The inflammatory disorders of the pancreas have two forms, acute and chronic. Acute pancreatitiscauses severe illness and reduces life expectancy. However, besides supportive care, there is no effectivetreatment for the disease due to a lack of understanding of the early cellular events important in thepathophysiology of this disease. Not only is chronic pancreatitis as bad in that it does not heal or improve andonly gets worse over time leading to permanent damage of the pancreas, it is also the top risk factor forpancreatic adenocarcinoma (PDAC).

Prostate cancer is the most common non-cutaneous cancer in American men. In May of 2012, the U.S. Preventive Task Force recommended that serum prostate specific antigen (PSA) screening no longer be recommended as standard clinical practice. A factor contributing to this recommendation is that many prostate cancers diagnosed via PSA-screening are indolent disease that will never progress. Current American Urologic Association recommendations stress informed decision making.

Uterine fibroids (UFs; leiomyomas) are the most important benign neoplastic threat to women's healthworldwide, but disproportionately affect women of color, particularly African American (AA) women, who have athreefold higher incidence rate and relative risk of UFs than Caucasian (CC) women. While the underlyingcause for this risk disparity is not fully understood, recent studies implicate hypovitaminosis D as a majorcontributor.