The primary objective of this study is to evaluate the efficacy of two (2) strengths of LUT0 14 Gel [0.3 mg/g (0.03% weight/weight, w/w) and 1.0 mg/g (0.10% w/w)] topically applied once a day (qd) for four (4) weeks in metastatic colorectal cancer (mCRC) patients with epidennal growth factor receptor inhibitor (EGFRI) induced Grade 2 acneifonn lesions compared to placebo.

An emerging challenge for tuberculosis (TB) control is the steadily rising number of individuals with type 2 diabetes (DM2). particularly in developing countries where TB is endemic. DM2 increases the risk of TB by three fold and there are now more people affected by TB-DM co-morbidity than TB-HIV infection. A better understanding of the link between TB and DM2 is essential to identify individuals at increased risk for TB progression. In DM2 patients. the interplay of hormones under neuroendocrine regulation. adipokines and insulin.

In light of the currently extant Covid pandemic. the impact of understanding upper airway health and being prepared for the rapid development of novel therapeutics has been reinforced. While preclinical animal models have long been the gold standard for the testing and development of novel therapeutics. they are expensive and time consuming. The availability of validated. reproducible and scalable in vitro diagnostics that reproduce relevant physiology and function as test-benches for the rapid testing and development of personalized medicine therapeutics is thus invaluable.

This research project will:(1) Perform analysis of deep-sequencing data from hundreds of samples. The workflow will include creating sequencing quality control (QC reports). merging overlapping pairs. trimming low quality reads. mapping reads to database. conducting OTU clustering. conducting abundance analysis and diversity analysis. and performing phylogenetic analysis and single nucleotide polymorphism (SNP) analysis. (2) Receive. process.

To determine pharmokinetic drug values of macrocyclic lactones from cattle serum and plasma.This project is in support of on going veterinary studies.

The goals of this project are to conduct vector and human surveillance of Chagas disease, and to propose policies for improved surveillance of this emerging infectious threat to our Service member population who reside and conduct training in potentially high risk areas.

The primary objective of this study is to assess the efficacy of Etrasimod when administered for twelve (12) weeks on clinical remission in subjects with moderately to severely Active Ulcerative Colitis (UC).

The Overall Study Sponsor has developed a study to assess the safety of vedolizumab versus other biologic agents in the real world setting. The participating physicians will be representative of the gastroenterologists who prescribe vedolizumab, or other biologic agents, per the local prescribing information in the participating countries.

Certain environmental signals in an infected host. such as hypoxia and nitrosative stress. starvation. and likely other yet-to-be defined factors. are thought capable of modulating Mycobacterium tuberculosis (Mtb) growth and may promote this pathogen to enter latency. although the precise cues remain incompletely defined1-4. Microarray study of Mtb under hypoxic or nitric oxide (NO) stress has identified an overlapping set of differentially expressed genes (termed the dormancy regulon); Rv2623. which encodes a universal stress protein (USP) homolog. is among the most up-regulated5-7.

The aim of the present study is to assess the safety, efficacy, and immunogenicity of AZD1222 for the prevention of COVID-19.