This T32 application seeks support for a Graduate Research in Immunology Program (GRIP) at the University of Texas Health Science Center San Antonio (UTHealthSA). GRIP will train three PhD, DDS/PhD and MD/PhD students per year for successful careers in academia, industry or government.

Candida albicans, the most commonly isolated human fungal pathogen, is responsible for a wide variety ofsystemic and mucosal infections. Immunocompromised individuals, including cancer patients onchemotherapy, AIDS patients, neonates, and organ transplant recipients, are particularly susceptible toinfection. The ability of C. albicans to undergo a reversible morphological transition from single budding yeastcells to filaments (elongated cells attached end-to-end) is important for virulence as well as several virulence-related properties.

Primary screening to take place at Calibr. Assays will be run in 1536wp format, using vital luciferase readouts at 48 and 72 hours post-infection (hpi) to detect compounds with activity throughout the P. berghei liver stage. Primary screening will be single concentration; the concentration to be screened will be determined based on library-specific recommendations, and approved by MMV.

The major goal is to use the relevant NHP model of TB and treatment with Type 1 neutralizing antibodies to specifically assess the functional role of Type 1 IFNs in disease progression from latency to PTB. Role: MPI

In vitro passages to accumulate mutations in non-essential genes for identifying in vivo virulence factorsAbstractInfertility due to tubal fibrosis/hydrosalpinx is a significant social and healthcare burden of sexuallytransmitted infection with Chlamydia trachomatis (CT). However, the pathogenic mechanisms remainunknown.

19-050 The major goal is to share the samples collected from the various cohorts of NHPs exhibiting latent as well as reactivation TB. Additionally, we will continue to perform data analysis on previous studies performed during the UH2 portion of the study. Role: MPI

Fellowship for Colwyn Headley.