As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Patterson, Jean L.
Funded by
Crucell Holland B.V.
TxBiomed is helping to develop a safe and effective Ebola/Marburg combination vaccine based on recombinant adenoviral vectors to induce protective immunity.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Xiang, Yan
Funded by
NIH
Poxviruses include some dangerous emerging or re-emerging pathogens as well as some promising vaccine vectors for infectious diseases and cancers. They are unique among viruses in that they encode a large number of proteins that are dedicated to evading host immune responses. These proteins include secreted inhibitors of cytokines as well as intracellular inhibitors of immune signaling or antiviral factors.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Baseman, Joel Barry
Funded by
NIH
The San Antonio Asthma and Allergic Diseases Cooperative Research Center (SA-AADCRC) represents a tightly focused, integrative and innovative effort to understand the role of Mycoplasma pneumoniae and its unique ADP-ribosylating and vacuolating toxin, designated Community Acquired Respiratory Distress Syndrome ToXin (CARDS TX) as important mediators of acute and chronic airway diseases, including new onset asthma and exacerbations, as well as persistent pulmonary dysfunction in children and adults.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Zhong, Guangming
Funded by
NIH
C. trachomatis proteomics: Whole genome scale mapping of C. trachomatis protective & pathogenic determinants. Chlamydia trachomatis urogenital tract infection causes inflammatory pathologies in the upper genital tract, which can lead to complications including tubal factor infertility. Understanding the pathogenic mechanisms and developing subunit vaccines have been the major focuses in modern chlamydial research. However, knowledge on chlamydial pathogenesis remains limited and there is no effective vaccine.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Zhong, Guangming
Funded by
NIH
C. trachomatis is the most frequently reported bacterial sexually transmitted disease in the US. In 2008, 1,210,523 chlamydial infections were reported to CDC (http://www.cdc.gov/std/stats08/trends.htm). If untreated, 10% of C. trachomatis-infected women may develop complications such as pelvic inflammatory diseases, ectopic pregnancy and infertility. The annual cost of treating C. trachomatis complications in women is >$2 billion.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Ahuja, Sunil K
Funded by
NIH
A critical determinant of interindividual differences in HIV-1 susceptibility and disease progression rates to AIDS is CCR5 expression levels. Delineating the mechanisms that modulate intersubject differences in CCR5 expression levels is thus of indisputable importance and significance for understanding HIV-AIDS pathogenesis, development of effective strategies for treatment, epidemiological studies and vaccination trials.
