The overall scope of the study is to determine if human monoclonal antibodies (hmAbs) shown in vitro to block SARS-CoV-2 infection are also effective, alone or in combination, in vivo using two rodent animal models of SARS-CoV-2 infection and associated COVID-19 disease.

This application is a request of the administrative supplement funds to the above parent grant to support a Hispanic graduate student. Mr. Samuel L. Montoya. for his graduate study in the Department of Chemistry at The University of Texas at San Antonio. A 24-month of financial support is budgeted for providing Mr. Montoya with salaries. tuition support. health insurance. and support of research-related training activities such as workshops and scientific conferences.

The major goal of the project is to understand COVID-19 in the elderly for the development of cures or vaccines.

This project is a pilot study to demonstrate that ELISPOT assays are performing adequately.

Pathogen-host cell interactions leading to Lyme disease will be interrogated at the single cell level.

For this proposal, we will assess three compounds for antiviral activity in a cell-based Lassa virus infection assay.

The central goal of this application is to demonstrate that recombinant forms of the prototypic mammarenavirus lymphocytic choriomeningitis virus (LCMV) containing a codon deoptimized (CD) nucleoprotein (NP) expressing glycoproteins (GP) of HF-causing LASV and JUNV (rLCMV/NPCD/GPHF) can be used for the development of a safe and protective individual or blended live-attenuated vaccine (LAV) to combat HF disease caused by LASV and JUNV infections.

The major goal of this is to assess the ability of Mtb-specific CD4 T cells from ART versus ART + IPT animals to active antimicrobial functions of Mtb-infected macrophages while promoting diversity.

The major goal of this study is to evaluate the cellular immune response to a cancer vaccine produced by Janssen.