This major goal of this funding is to outfit the Pathology Unit of SNPRC with a new chemistry analyzer, a new slide stainer and coverslipper, as well as seeks to purchase a state of the art whole slide scanner, which will provide a significant upgrade to research capabilities supported by Texas Biomed.

Core instrumentation for the Biology Core to expand the flow cytometry capabilities.

The purpose of this grant is for the purchase of a Confocal Microscope for Core Research Support project.

The major goal is to increase primate holding capacity for the P51 base grant.

The objective of this study is to define the amount and pattern of movement between the residual limb and the prosthetic socket during military relevant tasks and to leverage the information on limb/socket motion to develop algorithms lo identify these tasks for a controller used to adjust volume in an adaptable prosthetic socket.

The primary objective of this study is to conduct a Sequential Multiple Randomization Trial (SMART) comparing effectiveness and cost-effectiveness of Phase 1 and 2 treatments in a Stepped Care approach for patients with Lower Back Pain (LBP) in the Military Health System (MHS) with patient-centered and healthcare cost outcomes. Sub-aims will compare main effects of Phase 1 and 2 treatment options and the sequencing effects of different treatment combinations.

This project studys the role of connexin channels in anabolic function of mechanical loading. MicroCT and biomechanical property tests will be used and oversight will be provided for the studies of characterization of skeletal tissues of the mice subjected to loading models.

Bone fragility fractures are a major concern of health care of rapidly aging populations due to the high



risk of long-term disability and even mortality. Such fractures are not only due to loss of bone mineral density



(BMD), but also due to adverse changes at different structural hierarchies of bone, including ultrastructural



changes observed in bone disorders (e.g. osteogenesis imperfecta, mucopolysaccharidosis, and age-related

The research proposed here aims to optimize the delivery and functionality of a novel, biological therapy that bypasses the broad immunosuppressive mechanisms of current drugs in primary T cells, thereby addressing a major potential hurdle for this therapy.

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