Cognitive impairment has a serious detrimental impact on the quality of life for prostate cancer survivorstreated by androgen deprivation therapy (ADT). Neuroimaging studies have shown structural and functionaldeficits in the medial prefrontal cortex (mPFC) and hippocampus (Hipp), which mediate higher order cognitiveprocesses, including cognitive flexibility and spatial cognition, that are impaired after ADT. In this project, we willinvestigate mechanisms that underly the cognitive impairments we have now shown to be induced by androgendeprivation in rats.

Cognitive impairment has a serious detrimental impact on the quality of life for prostate cancer survivorstreated by androgen deprivation therapy (ADT). Neuroimaging studies have shown structural and functionaldeficits in the medial prefrontal cortex (mPFC) and hippocampus (Hipp), which mediate higher order cognitiveprocesses, including cognitive flexibility and spatial cognition, that are impaired after ADT. In this project, we willinvestigate mechanisms that underly the cognitive impairments we have now shown to be induced by androgendeprivation in rats.

The Integrated Graduate Program in Neuroscience at UTHSCSA provides training in a range of neuroscientific research areas and approaches, from molecular, cellular, and neurochemical to systems, behavioral and clinical neuroscience.

Cerebral Small Vessel Disease (SVD) is an important, potentially modifiable factor for clinical dementia. Recent data suggest that the age-specific incidence of dementia may be decreasing, partly as a result of bettermanagement of vascular risk factors, lending urgency to dementia prevention trials but a major impediment isthe absence of circulating biomarkers for tracking onset and progression of SVD.

The Integrated Graduate Program in Neuroscience at UTHSCSA provides training in a range of neuroscientific research areas and approaches, from molecular, cellular, and neurochemical to systems, behavioral and clinical neuroscience.