The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.
Principal Investigator(s)
McHardy, Stanton
Wang, Hua-Yu
Funded by
Southwest Res Inst
The Center for Innovative Drug Discovery (CIDD) will provide Southwest Research Institute (SwRI) with custom synthesis of Nav1.7 agonists. The CIDD will provide all the necessary services. highly experienced/qualified personnel. materials. equipment and the facilities to ensure the requested tasks are completed to meet the milestones and project timeline. The CIDD will provide the synthesis work to provide 10-20 mg supply of each of the 15 target Nav1.7 agonists. The general synthesis is outlined in the scheme below and the target compounds are exemplified in the shaded box.
The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.
Principal Investigator(s)
Hajiaghamemar, Marzieh
Funded by
Emory Univ
The outcomes of this research project provide opportunities to overcomes some of the challenges in successful translation of animal data into practical applications for humans such as predicting TBI and developing appropriate design criteria for impact sensor technology and protective equipment. In this project. we also develop axonal injury thresholds for repeated TBI for the first time. Abstract: Traumatic brain injury (TBI). particularly mild-TBI/ concussion.
The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.
Principal Investigator(s)
Gamblin, Truman
Funded by
NIH Natl Inst on Aging
This research project will compare the strains we generate with those we purify from AD and AD related neurodegenerative disorders such as progressive supranuclear palsy. If we are successful in identifying an artificial disease-relevant strain. we will continue our screening efforts to identify disease-relevant tau aggregation inhibitors while simultaneously working toward building a library of tau aggregate strains for multiple neurodegenerative tauopathies. These efforts will not only greatly increase the probability of generating effective therapeutics.
The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.
Principal Investigator(s)
Macpherson, Lindsey
Funded by
UTSA VPR Office
Brain Health Topic: Vagal signaling between the gut and the CNS contributes to appetite regulation. inflammation and immune responses. gastrointestinal motility. nausea. emesis. and even mood1-6 . Therefore. vagal neurons are an attractive target for medical interventions. Since vagal signaling may be modulated within the digestive tract. drugs need not cross the blood-brain barrier. reducing potential side effects and toxicity. To eventually identify potentially drug-able targets within the vagus to improve mental and digestive health.
