Schizophrenia remains one of the most disabling conditions world-wide with an economic burden thatexceeded $155 billion dollars in fiscal year 2013 alone. Despite existing medication and community treatment,many individuals with this diagnosis continue to have poor outcomes and struggle toward recovery.

The prevalence of endodontic pain ranges from 32-60% for irreversible pulpitis and ~60% for cases with apicalperiodontitis. Importantly, sex-related differences have been reported in these patients.

The Mentored Career Development (KL2; Core I) program of the Institute for Integrationof Medicine & Science has 3 primary objectives: 1) to develop clinical and translational scientists who caneffectively participate on interdisciplinary research teams; 2) to expand the workforce of clinical and translationalresearchers representing or focusing on our target populations: Hispanics, active-duty military personnel, andveterans; and 3) to collaborate actively with other CTSA hubs and the national CTSA Consortium.

Physicians recommend dietary interventions for management of cardiovascular disease,diabetes and many autoimmune diseases; however, there is a large gap in knowledge on the role ofdiet as a risk factor or potential therapy for chronic pain. Management of pain remains a substantialmedical problem, in part, because of an incomplete understanding of the physiologic mechanisms fortransduction and processing of noxious stimuli. Moreover, current analgesics are often limited byincomplete efficacy, unacceptable side effects or risk of dependency.