This proposal defines a continuation of a multi-disciplinary postdoctoral research training program toannually support six graduates of medicine, dentistry, veterinary medicine, or the basic biomedical sciences.This training program has an impressive record of successfully training young scientists over the past 34 years;of completed trainees in the past ten years (32) and those currently in the program (5), 34 of 37 (92%) arecurrently in science/medicine, 5 (14%) have held a MD degree, 11 (30%) have been from an underrepresentedpopulation in science, and 12 of 32 (38%) received independent

Disorders characterized by ischemia/reperfusion (I/R), such as myocardial infarction, stroke, andperipheral vascular disease, continue to be among the most frequent causes of devastating disease and maincauses of death in the US. Reperfusion of ischemic tissue triggers many pro-death signaling pathways whichconverge on to the mitochondria. Indeed, reoxygenation of cardiomyocytes leads to mitochondrial Ca2+overload and an increase in reactive oxygen species (ROS) generation that triggers the opening of themitochondrial permeability transition pore (mPTP).

This is a randomized, placebo-controlled, double-blind, parallel group, multicenter, CV outcomes study in subjects with HFrEF, including subjects with ongoing or history of HF hospitalization. The study is event-driven and will conclude when approximately 1590 CV death events have occurred. Approximately 8000 eligible subjects will be randomized in a 1:1 ratio to receive either OM or placebo.

Basic Research

Basic Research

Basic Research

Basic Research

Basic Research

Basic Research

An efficient method that can accurately analyze drug toxicities is in urgent demand for drug discovery