This research will be carried out via the training and mentoring of a graduate student in the joint graduate program in biomedical engineering to promote activities ongoing in the Extracorporeal Life Support capability area.Autonomous Reanimation and Evacuation Research to include the development. application and validation of extracorporeal life support devices.

The Center for Innovative Drug Discovery (CIDD) will provide Southwest Research Institute (SwRI) with custom synthesis of Nav1.7 agonists. The CIDD will provide all the necessary services. highly experienced/qualified personnel. materials. equipment and the facilities to ensure the requested tasks are completed to meet the milestones and project timeline. The CIDD will provide the synthesis work to provide 10-20 mg supply of each of the 15 target Nav1.7 agonists. The general synthesis is outlined in the scheme below and the target compounds are exemplified in the shaded box.

Human Immunodeficiency Virus (HIV) persists in the form of a ???latent reservoir??? hiding from complete eradication by the immune system or antiretroviral drugs. Current drugs eliminate actively multiplying HIV but are unable to eradicate the latent virus. Therefore. we hypothesize that a successful HIV RNA targeting strategy will efficiently and simultaneously target multiple conserved sites in HIV transcript. the possibility of concurrent alterations to which will either be negligible or entail fitness cost to the virus.

Basic Research

This research project is to perform an in vitro efficacy test of antifungal drug candidates that are produced by AmtixBio. Minimal inhibitory concentration (MIC) of the commensal fungus Candida albicans and two dermatophytes Tricophyton rubrum. and T. mantagrophytes will be determined.

Basic Research

Age-associated changes in immune function in old age are a known risk factor for tuberculosis (TB) however. the contribution of the heightened systemic inflammatory state (inflammaging) often observed in elderly individuals has not been previously considered. In Aim 1 we hypothesize that inflammation in the periphery will serve as a predictive biomarker of pulmonary inflammation and susceptibility to M.tb infection in old age.

Through this collaborative research project. the Center for Innovative Drug Discovery (CIDD) will provide Southwest Research Institute (SwRI) with process development support and chiral resolution of the target compound (+)-LP-184. The CIDD will provide all the necessary services. highly experienced/qualified personnel. materials. equipment and the facilities to ensure the requested tasks are completed to meet the milestones and project schedule.

The outcomes of this research project provide opportunities to overcomes some of the challenges in successful translation of animal data into practical applications for humans such as predicting TBI and developing appropriate design criteria for impact sensor technology and protective equipment. In this project. we also develop axonal injury thresholds for repeated TBI for the first time. 
 
 
 Abstract: 
 Traumatic brain injury (TBI). particularly mild-TBI/ concussion.

Basic Research