Proteins from the Fanconi anemia (FA) pathway play an integral role in DNA repair by homologousrecombination (HR). FA is a multigenic disorder marked by progressive bone marrow failure and astrong cancer predisposition. Numerous studies have linked mutations in FA genes to familial breast,pancreatic, and other cancers, and have also provided ample evidence to implicate silencing of FAgenes in the etiology of sporadic cancers.

Glioblastoma (GBM) is the most common and most aggressive of the primary malignant brain tumor in adults,with a median overall survival of 19.6 months following multi-modality therapy. The main limiting factor indelivering a tumoricidal radiation dose is the toxicity to surrounding brain. Therapeutic radionuclides, due to ashort tissue path and differences in radiobiology, have the potential to extend the therapeutic window for radiationin GBM.

Cognitive deficits are major disabling impairments associated with autism and schizophrenia. Because theunderlying genetic and cellular mechanisms of such deficits are still poorly understood, mechanism-basedtherapeutic options do not exist, limiting the effective integration of patients into society. Previous clinical workhas shown that executive functions such as working memory and cognitive flexibility start to lag behind fromadolescence to adulthood in individuals with autism and schizophrenia.