ThisT32applicationseekssupportforaGraduateResearchinImmunologyProgram(GRIP)attheUniversityofTexasHealthScienceCenterSanAntonio(UTHealthSA).GRIPwilltrainthreePhD,DDS/PhDandMD/PhDstudentsperyearforsuccessfulcareersinacademia,industryorgovernment.Itintegratestheresearchactivitiesof the UT Long School of Medicine basic science and clinical departments/centers, which includes the NCI-Designated UT Health MD Anderson Cancer Center SA, the NIH/CTSA-supported UT Health Institute forIntegrationofMedicineandScience(UTIIMS),aswellasthelocalaffiliateTexasBiomedicalResearchInstituteand UT System sister

Discretionary control of renal Na+ transport matches renal Na+ excretion with dietary Na+ intake. Because Na+excretion can influence blood pressure, disordered renal Na+ transport in many instances causes abnormalblood pressure. Moreover, as we know from the actions of most diuretics and many tubulopathies interdictionof normal renal Na+ transport changes blood pressure. Renal sodium excretion is fine-tuned in response tohormonal signaling in the aldosterone-sensitive distal nephron (ASDN).

Aberrant intracellular calcium ([Ca2+]i) homeostasis has been implicated in cardiovascular diseases (CVD) which contributes to endothelial dysfunction. Ca2+ acts as a second messenger and is known to regulate several cell functions. Despite the available evidence of a link between Ca2+ signaling and endothelial dysfunction, mechanisms underlying the development of vascular disease remain incompletely understood. Besides Ca2+, reactive oxygen species have also been implicated in endothelial cell (EC) dysfunction.

Over 47% of family members who care for a relative with Alzheimer?s disease or a related dementia (ADRD) engage in physical or psychological abuse or neglect. Cross-sectional studies report caregiver stress and behavioral symptoms of dementia are correlated with elder abuse and neglect (EAN), making the caregiver burden theory the leading explanation for EAN.

The Mentored Career Development (KL2; Core I) program of the Institute for Integrationof Medicine & Science has 3 primary objectives: 1) to develop clinical and translational scientists who caneffectively participate on interdisciplinary research teams; 2) to expand the workforce of clinical and translationalresearchers representing or focusing on our target populations: Hispanics, active-duty military personnel, andveterans; and 3) to collaborate actively with other CTSA hubs and the national CTSA Consortium.