The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Walter, Christi A
Funded by
NIH-NATIONAL INSTITUTE ON AGING
Children with a genetic disease or birth defect are hospitalized at a younger age, stay longer, and have ahigher death rate than children hospitalized for other reasons. One in 33 infants born in the US has a birthdefect; the number one cause of infant mortality. Our long-term goal is to change these dire statistics bydelineating the mechanisms that reduce game quality by increasing mutagenesis in male gametes withincreasing age, i.e., the paternal age effect.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Paukert, Martin
Funded by
NIH-NATL INSTITUTE OF MENTAL HEALTH
Awake behavior is accompanied by fluctuations in vigilance shaping the overall activity state of the brain tooptimize cellular and circuit activity. The cellular and molecular mechanisms for such brain state-dependentadjustments in neural activity are not well understood. Using a mouse locomotion paradigm we have recentlyfound that the transition from a resting state to active locomotion is associated with release of theneurotransmitter norepinephrine and leads to Ca2+ activation of astroglia.
