The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Paukert, Martin
Funded by
NIH-ALCOHOL ABUSE & ALCOHOLISM
Alcohol consumption impairs motor coordination, attentional efforts and memory function. Alcohol-impaireddriving accounted in 2013 for ~31% of all traffic accidents resulting in 10,076 fatalities and $59 billion crash-related cost. We propose to study the mechanisms how ethanol affects brain state-dependent neuralsignaling. Brain state-dependent signaling comprises adjustments in cellular and circuit activity to optimizehow the brain processes information in a distinct behavioral context.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Tumanov, Alexei V
Funded by
NIH-ALLERGY & INFECTIOUS DISEASES
Campylobacter is a major human pathogen that infects an estimated 2.5 million people each year resulting in anestimated $1.9 billion economic loss in the U.S. Campylobacter jejuni is a common human enteric pathogen thatcauses acute enterocolitis and increases the risk of developing long-term intestinal dysfunction such as post-infectious irritable bowel syndrome. The innate immune mechanisms responsible for intestinal pathology in C.jejuni-induced colitis are still poorly understood.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Ramirez, Amelie G
Funded by
NIH-CTR MINORITY HEALTH/HLTH DISPARITIES
Advancing the Science of Cancer in LatinosProject Summary/AbstractThe proposed conference, ?Advancing the Science of Cancer in Latinos,? would occur February21-23, 2018, in San Antonio, Texas.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Yeh, Chih-Ko
Funded by
NIH-DENTAL & CRANIOFACIAL RESEARCH
Collaborating Institutions
UTSA
Saliva is an important defense mechanism for protecting oral health. Salivary gland (SG) hypofunctionresults in uncontrolled and severe oral diseases that lead to severely compromised quality of life. SGsare highly differentiated and have little regenerative capacity once they are destroyed by therapy ordisease (e.g. radiation therapy or autoimmune Sjgren?s syndrome). Therefore, the development ofstrategies for preserving or regenerating the secretory function of SGs is essential for successfulmanagement of these patients.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Reeves, William Brian
Funded by
NIH-DIABETES/DIGESTIVE/KIDNEY DISEASES
Acute kidney injury (AKI) is a common and often fatal event. Inflammation plays a key role in the pathogenesis of AKI. Relatively little is known regarding the endogenous pathways which limit inflammation and reduce the incidence and/or severity of AKI. We recently determined that resident dendritic cells (DCs) and endogenous IL-10 are anti-inflammatory and reduce the severity of AKI. Moreover, the protective actions of dendritic cells are partially dependent upon their production of IL-10.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Han, Xianlin
Funded by
NIH-GENERAL MEDICAL SCIENCES
A big concern has recently arisen regarding the safety of anesthesia in infants and children based on the profoundly increasing preclinical evidences in rodents and nonhuman primates that the commonly used anesthetics in clinic are neurotoxic to the developing brain and may cause long-term neurobehavioral abnormalities. Hence, the clinical relevance of anesthetic neurotoxicity as well as the development of biomarkers for early detection of anesthetic-induced neuronal injury is an urgent matter of public health.