The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Kadosh, David
Funded by
NIH
Candidiasis represents the third leading cause of hospital-acquired bloodstream infections in the U.S. Candida albicans, the most commonly isolated human fungal pathogen, is associated with 50% of infections while several non-albicans Candida species (NACS), including Candida tropicalis and Candida parapsilosis, account for the remainder of cases. Only three major classes of antifungals are currently available for treatment and there is a significant demand for new and more effective therapies. A major virulence property of C.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Daws, Lynette C
Funded by
NIH
Depression is a major public health problem for which the majority of patients are not effectively treated. This problem is exacerbated further in children and adolescents for whom only two antidepressant drugs are currently approved. Both belong to the selective serotonin (5-HT) reuptake inhibitor (SSRI) class of antidepressant, and act by blocking high-affinity uptake of 5-HT from extracellular fluid via the serotonin transporter(SERT).
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Martinez-Anz, Sabrina Patrice
Funded by
NIH
Candida species are the fourth leading cause of hospital-acquired bloodstream infections in the United States with an attributable mortality rate of 40-50%. Oral candidiasis is the most common fungal infection encountered in the general dental practice and immunocompromised individuals, including AIDS patients, are particularly susceptible. Candida albicans is the most frequently isolated species in oral thrush patients. C. albicans and C. glabrata are increasingly being co-isolated from fungal lesions in the oral cavity.C.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Houston, Tiffani J
Funded by
NIH
Inorganic arsenic (iAs) is the highest-ranking toxin on the U.S. substance priority list. Chronic exposure through natural water sources is linked to a broad range of adverse health effects, including pathological changes in the urinary bladder. Due to the make up of the urothelial cell, iAs readily accumulates to elicit toxic effects. However the specific mechanisms of arsenic-induced urothelial injury are not fully characterized. Upon cell injury there is rapid influx of inflammatory mediators and increase in cellular inflammatory signaling.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Aguilar, David Dominguez
Funded by
NIH
This project aims to explore the interaction of genetic and environmental factors in the development of psychotic symptoms. Cannabinoid exposure during adolescence is associated with an increased risk of developing schizophrenia, but this correlation is not causative. Thus, it is likely that people with a genetic predisposition to psychotic symptoms are more strongly affected by environmental risk factors.
