The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.
Principal Investigator(s)
Paladini, Carlos
Norepinephrine (NE) provides excitatory drive onto midbrain dopamine (DA) neurons and modulates responses to dopaminergic drugs, including psychostimulants. Chronic loss of noradrenergic tone impairs DA neuron firing and DA release, leading to compensatory alterations in postsynaptic DA receptor signaling and a paradoxical hypersensitivity to dopaminergic drugs. The goal of this proposal is to identify the molecular and cellular mechanisms underlying the behavioral hypersensitivity to cocaine following chronic inhibition of the NE biosynthetic enzyme, dopamine -hydroxylase (DBH).
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Olena Shtanko
Funded by
NIH
Collaborating Institutions
University of Iowa
We will be responsible for BSL4 experiments involving Ebola virus infection of treated and untreated murine macrophages.
The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.
Principal Investigator(s)
Hsieh, Jenny
Funded by
UTSA VPR Office
The `opioid epidemic' is one of the most significant health issues facing this country today with rates of opioid-associated deaths up 200% since 2000. This epidemic is also taking its toll on pregnant women and their babies, with an annual average of ~21,000 pregnant women ages 15 to 44 who have misused opioids this past month. Infants who have been exposed to opioid drugs exhibit an increased risk of neurological and behavioral consequences.
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Kadosh, David
Funded by
NIH-ALLERGY & INFECTIOUS DISEASES
Collaborating Institutions
USC UTSA
Candidiasis has remained the most common opportunistic oral infection in HIV positive individuals and AIDSpatients. Even following the introduction of highly active antiretroviral therapy (HAART) approximately 30% ofAIDS patients acquire oropharyngeal candidiasis (OPC). Candida albicans, the main causative agent of OPC,forms complex aggregated microbial communities, known as biofilms, on host oral mucosal surfaces whichplay an important role in establishing infections called ?oral thrush?. C.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Zhang, Nu
Funded by
NIH-ALLERGY & INFECTIOUS DISEASES
Infectious diseases pose a significant public health burden, accounting for nearly one-fifth of deaths globallyper annum. Most infections are initiated from a restricted mucosal tissue, such as the intestine. To fightintestinal infections, gut-resident immune cells are superior to circulating ones. There is a surge of recentinterest in tissue-resident memory T (TRM) cells that have been shown to be a critical adaptive immunecomponent of mucosal immunity. These cells have been flagged as an ideal cell population to be generated inT cell-based vaccines.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Hargreaves, Kenneth M
Funded by
NIH-DENTAL & CRANIOFACIAL RESEARCH
Numerous studies indicate that women and men differ in prevalence of pain disorders or pain intensity,possibly due to sexually dimorphic differences in detection, processing or responses to noxious stimuli. Here,we propose to study a peripheral sexually dimorphic pain mechanism that occurs in humans. The importanceof this complex problem has been emphasized by recent NIH policies (NOT OD 15-102).
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
DeFronzo, Ralph A
Funded by
NIH-DIABETES/DIGESTIVE/KIDNEY DISEASES
Inhibition of the renal SGLT2 transporter has proven to be an effective therapeutic interventionto reduce plasma glucose levels and HbA1c in type 2 diabetic patients. The glycemic-loweringefficacy of the SGLT2 inhibitors results from two distinct mechanisms: (i) induction ofglucosuria, which amounts to ~70-90 grams per day and (ii) amelioration of glucotoxicity leadingto increased insulin sensitivity in muscle and improved beta cell function (JCI 124:509-514,2014).