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Physicians recommend dietary interventions for management of cardiovascular disease,diabetes and many autoimmune diseases; however, there is a large gap in knowledge on the role ofdiet as a risk factor or potential therapy for chronic pain. Management of pain remains a substantialmedical problem, in part, because of an incomplete understanding of the physiologic mechanisms fortransduction and processing of noxious stimuli. Moreover, current analgesics are often limited byincomplete efficacy, unacceptable side effects or risk of dependency.

UT Health San Antonio
Boyd, Jacob T

This is a randomized, double-blind, placebo-controlled phase 3 study designed to compare the OS between patients treated with HMA plus vadastuximab talirine (experimental arm) versus patients treated with HMA plus placebo (comparator arm). Patients will be randomized in a 1:1 manner to one of the study arms. Investigators may select either HMA (azacitidine or decitabine).

Brooke Army Medical Center
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